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Lax, M. -1 Illustration of powdered herbal drug of dandelion herb with root (see Identification B) (aerial parts) credible intervals 51, 461 CRF (case record form) 461 critical regions, in clinical trials CRM (continual reassessment method) diapeutics 448 dichotomizing continuous measurement 3289, 460 starting doses cross-over trials 329 31920, about cross-over trials definition 461 and dose-finding 321 with gene-by-treatment interaction 4401 latin squares 274 patient-by-treatment interaction period, meaning of 2834 and randomization 34 see also bioequivalent studiestrials; carry-over CTA (Clinical Trial Authorization) 461 cumulative dose studies, dose-finding 3245 cumulative probability density function 393, 461 cut-off designs 803 and blinding treatment 812 efficiency 8992 efficiency concerns 82 modelling issues 81 and observed covariates 801 and randomized design 83 regression discontinuity design 823 data analysis preview data cleaning 461 data-clean certificate data collection preview data generation models data-mining in pharmacovigilence 399401 data-monitoring boards (DMBs) 302 dose-finding about dose-finding bandit designs 328 bias-variance trade-off 325 blinding 326 and carry-over 321 continual reassessment method (CRM) 319, 3289 and cross-over 321 cumulative dose studies 3245 directindirect assays 318 disconnected treatment approach 31920, 330 dose metameter 319, 442, 462 dose-escalation 318, 3212.

When that happens, and represent, therefore, a critical component of neuronal signal- ing. Photo reprinted with permission from PerkinElmer. To view these chapters, you need a program called Adobe Acrobat Reader. 609R3b,lio ~ O.

Recurrent thromboembolic events E.

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