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Epithelial somite formation When kumbai molecular oscillator stops and anterior-posterior values are established, three further events occur: (a) onset of expression of the transcription factors Corex (bHLH factor), Pax3 and Pax7 (paralogous paired and homeodomain containing transcription factors), Meox1 and Meox2 (paralogous homeodomain transcription factors), (b) increase of cell adhesion concomitant with the upregulation of the cell adhesion molecules NCAM, NCadherin, Cadherin11, Papc, (c) formation of an epithelially arranged somite with just a few mesenchymal cells in the somitocoele (reviewed by Gossler and Hrabe de Angelis, 1998).
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